The glomerular basement membrane

basic research and clinical aspects in paediatric nephrology by Gert Lubec

Publisher: Maudrich in Wien

Written in English
Published: Pages: 78 Downloads: 403
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  • Glomerulonephritis -- Immunological aspects,
  • Membrane Basement,
  • Pediatric nephrology

Edition Notes

Includes bibliographies.

StatementGert Lubec.
LC ClassificationsQH601 L8
The Physical Object
Pagination78 p. :
Number of Pages78
ID Numbers
Open LibraryOL19358526M
ISBN 103851753259

This group of renal diseases is characterized by primary abnormalities of the glomerulus, both structural (inflammation, cellular proliferation, basement membrane thickening, fibrosis, epithelial cell changes) and functional (increased permeability causing pro-teinuria or hemorrhage of glomerular origin). The glomerular filtration barrier is a highly specialized capillary wall comprising fenestrated endothelial cells, podocytes, and an intervening basement membrane. In glomerular disease, this barrier loses functional integrity, allowing the passage of macromolecules and cells, and there are associated changes in both cell morphology and the extracellular matrix. Over the past 3 decades, there.   Anti-glomerular basement membrane (GBM) disease is an uncommon autoimmune disease which usually follows a self-limited course [1]. It has been known that the predominant pathogenic autoantibody is the IgG isotype and is directed against to the non-collagenous domain of alpha-3 chain of type IV collagen [2,3]. Question: Nephrotic Syndrome Results From An Increased Permeability Of The Glomerular Basement Membrane As A Result Of Mononuclear Cells Releasing Cytokines. What Histological Features Form The Filtration Membrane? How Is Glomerular Filtrate Composition Altered In This Medical Condition? Predict How The Body Responds To Maintain Homeostasis As A Result Of These.

Review Topic QID: 1 Normal kidney biopsy, no pathological finding is evident at this time 2 Glomerular hypertrophy with slight glomerular basement membrane thickening [] [ ] nephrotic syndrome occurring most commonly in children, in which glomeruli show minimal changes with no thickening of the basement membranes, fat. Thin basement membrane disease (TBMD, also known as benign familial hematuria and thin basement membrane nephropathy or TBMN) is, along with IgA nephropathy, the most common cause of hematuria without other symptoms. The only abnormal finding in this disease is a thinning of the basement membrane of the glomeruli in the kidneys. Its importance lies in the fact that it has a benign prognosis. GBM: Antibodies to glomerular basement membrane (GBM) antigens cause glomerulonephritis, Goodpasture syndrome (glomerulonephritis, often with rapid onset renal failure, and pulmonary hemorrhage), and, less commonly, pulmonary hemosiderosis.(1) Nephrogenic GBM antigens are associated with the noncollagenous carboxyl extension of type IV procollagen. These images are a random sampling from a Bing search on the term "Glomerular Basement Membrane Antibody." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images this collection now contains interlinked topic pages divided into a tree of 31 specialty books and

INTRODUCTION: Anti-GBM disease is a small vessel vasculitis affecting glomerular and pulmonary capillaries due to deposition of anti-GBM autoantibodies along basement membrane. It is characterized by a triad of pulmonary hemorrhage, crescentic glomerulonephritis and circulating anti-GBM autoantibodies (1).

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Glomerular Basement Membrane The GBM is a specialized structure that envelops the peripheral capillary loops and the paramesangial areas and is continuous with the basement membrane of Bowman's capsule at the vascular pole of the glomerulus. The GBM is one of the thickest basement membranes in the body.

BOOK REVIEW Book Review: Glomerular Basement Membrane Edited by G. Lubec and B. Hudson Glomerular Basement Membrane (John Libbey & Company, Ltd, London, ) consists of 28 contributions of timely topics by a worldwide group of investigators dealing with basic and clini­ cal problems involving the glomerular basement.

Basement Membranes: Cell and Molecular Biology brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes.

It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular. As basement membranes have been shown to be defective in numerous genetic and acquired diseases and to contribute to the microenvironment of both tumor cells and stem cells, this book presents a view of specific basement membrane components and their roles in development and disease, all written and commented on in chapters written by leaders in the basement membrane : $   Abstract A detailed morphometric analysis of glomerular basement membrane (GBM) thickness was carried out on biopsies from 16 patients exhibiting normal histology and unremarkable immunofluorescence.

Eleven of these patients presented with proteinuria, 8 in the nephrotic syndrome range, while 5 had hematuria as well. The microtiter plate has been pre-coated with a monoclonal antibody specific for Glomerular Basement Membrane Antibody (GBM) (Monkey).

Standards or samples are then added to the microtiter plate wells and if the protein is present, will bind to the antibody pre-coated wells. In order to quantitatively determine the amount of protein present in. The kidney's glomerular filtration barrier consists of two cells-podocytes and endothelial cells-and the glomerular basement membrane (GBM), a specialized extracellular matrix that lies between them.

Like all basement membranes, the GBM consists mainly of laminin, type IV collagen, nidogen, and heparan sulfate proteoglycan. The glomerular basement membrane is the fused basement membrane of both the endothelial cell The glomerular basement membrane book and the podocyte cell layer.

The endothelial cells have a glycocalyx coat that is extended to form the endothelial surface layer, over nm thick. The charges in this layer may be important in restricting plasma protein filtration. Glomerular Basement Membrane Antibody (IgG) - Glomerular Basement Membrane Antibody is present in one fourth of patients The glomerular basement membrane book Goodpasture's syndrome.

This syndrome consists of glomerulonephritis and pulmonary hemorrhage. openings between the endothelial cells of the glomerular capillaries. gaps between the podocyte processes in the visceral layer of Bowman's capsule.

basement membrane of the glomerular endothelium. active transport channels. The glomerular basement membrane of the kidney is the basal lamina layer of the glomerular endothelial cells, the glomeular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule.

[1] The glomerular basement membrane is a fusion. The anti-glomerular basement membrane (anti-GBM) test looks for anti-glomerular basement membrane antibodies that attack a part of the kidney known as the glomerular basement membrane (GBM).

Anti-Glomerular Basement Membrane Disease, An Update on Glomerulopathies - Clinical and Treatment Aspects, Sharma S. Prabhakar, IntechOpen, DOI: / Available from: Kouichi Hirayama and Kunihiro Yamagata (November 2nd ).

The glomerular filtration membrane or the glomerular capillary wall consists of three layers – the glomerular capillary endothelium, basement membrane of the glomerular, and the epithelial podocytes of Bowman’s capsule.

A single layer of endothelial cells that are attached to the basement membrane forms the glomerular capillary membrane. Glomerular Basement Membrane COL4A4 Gene Alport Syndrome Slit Diaphragm Lamina Densa These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

The glomerular basement membrane (GBM) of the kidney is the basal lamina layer of the glomerulus. The glomerular endothelial cells, the GBM and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule.

Cationized ferritin (CF) of narrow pI range () and the basic dye ruthenium red (RR) have been used as cationic probes to partially characterize anionic sites previously demonstrated in the glomerular basement membrane (GBM).

Family Practice Notebook ©, Family Practice Notebook, LLC. Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers. The physicochemical characteristics of the glomerular capillary filtration membrane restrict the passage of macromolecules on the basis of molecular weight, charge, and shape.

The proposed ionic charge permselectivity characteristics of the glomerular basement membrane (GBM) are determined by its chemical composition, primarily the highly sulfated glycosaminoglycan heparan.

Definition Anti-glomerular basement membrane diseases (anti-GBM diseases) is a rare disorder that can involve quickly worsening kidney failure and lung disease.

Some forms of the disease involve just the lung or the kidney. Anti-GBM disease used to be known as Goodpasture syndrome. Rats were induced anti-glomerular basement membrane glomerulonephritis and treated with atorvastatin (20 mg/kg/day) or vehicle (control).

Control rats showed infiltration of macrophages in the glomeruli at day 3 and developed crescentic glomerulonephritis by day 7, together with increased mRNA levels of the M1 macrophage-associated cytokines. Anti-Glomerular Basement Membrane Antibody Deposition; In this scenario, a specific antibody develops that binds to a normal protein component of the GBM, in essence a form of Type II Hypersensitivity.

Here, no immune complexes are present and instead the antibody diffusely deposits along the entire length of the GBM. Anti-GBM antibody. The basement membrane is composed of proteins secreted by the two layers of cells, but little was known about how these proteins are organized.

Now, Suleiman et al. have adapted a new form of high-resolution optical microscopy called STORM to study the structure of the glomerular basement membrane in both mouse and human kidney tissue. Strong linear glomerular basement membrane staining for alpha 3 and 4 protein (similar to normals, Arch Pathol Lab Med ;), positive antibody staining to NC1 domain of glomerular basement membrane from patients with thin basement membrane disease Occasional IgM and IgG.

The glomerular basement membrane is the part of the kidney that helps filter waste and extra fluid from the blood. Anti-glomerular basement membrane antibodies are antibodies against this membrane. They can lead to kidney damage. This article describes the blood test to detect these antibodies.

The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Antiglomerular basement membrane antibodies are antibodies against this membrane. They can damage the basement membrane, which can lead to kidney damage. A diagnosis of anti-GBM antibody disease is made when a patient presents with lung hemorrhage, urinary findings such as proteinuria (protein in the urine) and hematuria (blood in the urine), and circulating anti–glomerular basement membrane (anti-GBM) antibodies.

A kidney biopsy is the best method for detecting anti-GBM antibodies in tissues. Thin glomerular basement membrane nephropathy appears to be far more common than Alport syndrome, occurring in approximately 1% of the population compared with % for Alport syndrome,26 Still, as noted above, there is considerable phenotypic overlap between individuals.

Anti-glomerular basement membrane (anti-GBM) disease, also known as Goodpasture’s disease, is a rare but life-threatening condition that is characterized by circulating and deposited antibody directed against the GBM, which presents with features of crescentic glomerulonephritis, with or without concomitant pulmonary hemorrhage.

When present, IgG antibody to glomerular basement membrane (GBM) antigen detected by either indirect fluorescent antibody (IFA) or multiplex bead assay helps support a diagnosis of Goodpasture syndrome. However, the combined result of both assays performed during initial evaluation improves the diagnostic sensitivity for disease.

The glomerular basement membrane is the part of the kidney that helps filter waste and extra fluid from the blood. Anti-glomerular basement membrane antibodies are antibodies against this membrane. They can lead to kidney damage. This article describes the .The glomerular basement membrane (GBM) is a crucial component of the kidney's filtration barrier that separates the vasculature from the urinary space.

During glomerulogenesis, the GBM is formed from fusion of two distinct basement membranes, one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular.Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane.

Forces are highest within the filtration slits.